HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 27249171, 31404116, 11259596, 10921914, 33768585, 14633987, 12609980, 19843958, 12242293, 22851693, 19232515, 19521662, 22643835, 16517750, 21822258, 25963657, 26038599, 27501752, 28024152, 31127032 and 14 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, enzymatic study, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002726 - positive regulation of T cell cytokine production
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0005634 - nucleus
and 17 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 606
Hs

1 522
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Last updated: 15 Jul 2024