HitPredict

Interactor 1: DHH (O43323)
Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product (DHH-N)]
Gene: DHH

Interactor 2: HHIP (Q96QV1)
Hedgehog-interacting protein (HHIP) (HIP)
Gene: HHIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	19561611, 19561609
Identification Methods	static light scattering, surface plasmon resonance, molecular sieving, x-ray crystallography, solid phase assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	GSDH~HH_signal
Common GO terms	GO:0005886 - plasma membrane GO:0008270 - zinc ion binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 396 Hs			1 700
+	Mm
		1143678 SHH_MOUSE (1-395): 0: 623: 56.50		HHIP_MOUSE (1-700): 0: 702: 94.29
+	Hs
		1056176 IHH_HUMAN (20-385): 0: 615: 59.84		HHIP_HUMAN (1-700): 0: 702: 100.00
+	Hs
		1074301 SHH_HUMAN (20-395): 0: 578: 54.08		HHIP_HUMAN (1-700): 0: 702: 100.00
+	Dm
		973718 HH_DROME (4-395): 0: 552: 49.39		WIF1_DROME (593-667): 5.78e-16: 82.9: 35.53