Interactor 1: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2
Interactor 2: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.94 | 1.00 | 0.971 |
The method score is based on:
Property | Details |
---|---|
Experiments | 25416956, 27045108, 32296183, 21123652, 16824733, 19337385, 10880512, unassigned1304, 14743216 |
Identification Methods | two hybrid, enzymatic study, in-gel kinase assay, anti tag coimmunoprecipitation, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid, tandem affinity purification |
Interaction Type | direct interaction, phosphorylation reaction, physical association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | CARD~CARD, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr |
Common GO terms | GO:0001961 - positive regulation of cytokine-mediated signaling pathway GO:0002250 - adaptive immune response GO:0002827 - positive regulation of T-helper 1 type immune response GO:0004674 - protein serine/threonine kinase activity GO:0004706 - JUN kinase kinase kinase activity and 73 others more... |
Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores
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Last updated: 15 Jul 2024