Interactor 1: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Interactor 2: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.971

The method score is based on:

Property Details
Experiments 25416956, 27045108, 32296183, 21123652, 16824733, 19337385, 10880512, unassigned1304, 14743216
Identification Methods two hybrid, enzymatic study, in-gel kinase assay, anti tag coimmunoprecipitation, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid, tandem affinity purification
Interaction Type direct interaction, phosphorylation reaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001961 - positive regulation of cytokine-mediated signaling pathway
GO:0002250 - adaptive immune response
GO:0002827 - positive regulation of T-helper 1 type immune response
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity
and 73 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 540
Hs

1 540
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Last updated: 15 Jul 2024