HitPredict

Interactor 1: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

The method score is based on:

Property	Details
Experiments	9705938, 14634131, 11051551, 11536016, 15039421, 16585594
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CARD~CARD
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0007165 - signal transduction and 6 others more... GO:0032731 - positive regulation of interleukin-1 beta production GO:0032991 - protein-containing complex GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0050700 - CARD domain binding GO:0089720 - caspase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	540
Hs

1	404

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024