HitPredict

Interactor 1: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 540 Hs			1 248
+	Hs
		201777 RIPK2_HUMAN (1-540): 2.07e-168: 489: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	At
		1277300 SERK1_ARATH (3-319): 1.23e-128: 390: 24.63		14337_ARATH (2-247): 4.35e-147: 413: 58.07
+	At
		965327 PBS1_ARATH (7-391): 7.64e-134: 398: 18.59		14332_ARATH (3-248): 2.23e-144: 405: 58.47
+	At
		965320 BAK1_ARATH (3-337): 3.6e-131: 397: 24.22		14332_ARATH (3-248): 2.23e-144: 405: 58.47
+	Hs
		201757 RIPK2_HUMAN (1-540): 2.07e-168: 489: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		201763 RIPK2_HUMAN (1-540): 2.07e-168: 489: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		201776 RIPK2_HUMAN (1-540): 2.07e-168: 489: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		201784 RIPK2_HUMAN (1-540): 2.07e-168: 489: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	At
		788521 PBL9_ARATH (3-294): 7.75e-100: 309: 24.61		14333_ARATH (3-247): 2.63e-144: 405: 58.30
+	Hs
		910023 Q9H4D1_HUMAN (27-291): 9.27e-57: 204: 44.32		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		927522 Q9H4D1_HUMAN (27-291): 9.27e-57: 204: 44.32		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647273 Q9H4D1_HUMAN (27-291): 9.27e-57: 204: 44.32		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		646759 RIPK4_HUMAN (27-283): 3.4e-56: 203: 44.91		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683652 Q96T11_HUMAN (27-291): 3.23e-57: 206: 44.69		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		683708 Q9H4D1_HUMAN (27-291): 9.27e-57: 204: 44.32		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		683234 RIPK4_HUMAN (27-283): 3.4e-56: 203: 44.91		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		905022 Q96T11_HUMAN (27-291): 3.23e-57: 206: 44.69		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		905108 Q9H4D1_HUMAN (27-291): 9.27e-57: 204: 44.32		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982413 Q96T11_HUMAN (27-291): 3.23e-57: 206: 44.69		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		982494 Q9H4D1_HUMAN (27-291): 9.27e-57: 204: 44.32		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20