HitPredict

Interactor 1: HNRPR (O43390)
Heterogeneous nuclear ribonucleoprotein R (hnRNP R)
Gene: HNRNPR

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	20020773, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 633 Hs			1 414
+	Hs
		235830 HNRPQ_HUMAN (3-633): 1.1e-116: 363: 78.17		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		202148 HNRPR_HUMAN (1-633): 1.8e-124: 383: 100.00		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		235835 HNRPQ_HUMAN (3-633): 1.1e-116: 363: 78.17		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		1025860 RBM46_HUMAN (103-466): 2.76e-70: 239: 47.54		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Mm
		857343 HNRPQ_MOUSE (3-633): 2.52e-116: 362: 78.17		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		47724 RBM47_HUMAN (114-563): 1.08e-88: 289: 45.03		MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93
+	Hs
		235683 HNRPQ_HUMAN (3-633): 1.1e-116: 363: 78.17		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		202161 HNRPR_HUMAN (1-633): 1.8e-124: 383: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Mm
		857321 Q3UZI0_MOUSE (53-633): 5.98e-106: 334: 98.45		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		235854 HNRPQ_HUMAN (3-633): 1.1e-116: 363: 78.17		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		47770 RBM47_HUMAN (114-563): 1.08e-88: 289: 45.03		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		47742 RBM47_HUMAN (114-563): 1.08e-88: 289: 45.03		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		1025728 PABP4_HUMAN (69-235): 3.94e-23: 106: 14.44		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		162035 PABP4_HUMAN (69-235): 3.94e-23: 106: 14.44		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		474021 PAB4L_HUMAN (166-433): 5.14e-55: 193: 21.20		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		161948 PABP1_HUMAN (69-235): 3.67e-20: 96.6: 16.20		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Mm
		665745 PABP1_MOUSE (69-235): 3.28e-20: 97: 16.20		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		516495 PABP4_HUMAN (69-235): 3.94e-23: 106: 14.44		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516689 PABP3_HUMAN (69-235): 4.88e-21: 99.7: 15.64		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95