HitPredict

Interactor 1: PRPF3 (O43395)
U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein)
Gene: PRPF3

Interactor 2: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

The method score is based on:

Property	Details
Experiments	34144037, 28515276, 35271311, 20595234
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PRP3~PRP8_domainIV
Common GO terms	GO:0000244 - spliceosomal tri-snRNP complex assembly GO:0000375 - RNA splicing, via transesterification reactions GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus and 6 others more... GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0008380 - RNA splicing GO:0016607 - nuclear speck GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071005 - U2-type precatalytic spliceosome
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	683
Hs

1	2335

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024