HitPredict

Interactor 1: TXNL1 (O43396)
Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)
Gene: TXNL1

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22645313, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 289 Hs			1 875
+	Hs
		983131 PDIA6_HUMAN (5-158): 2.41e-30: 119: 15.63		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		671793 PDIA3_HUMAN (5-116): 2.37e-22: 98.3: 15.25		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		671744 PDIA3_HUMAN (5-116): 2.37e-22: 98.3: 15.25		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		531754 PDIA4_HUMAN (3-115): 1.12e-20: 93.7: 18.33		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		495611 THIO_HUMAN (4-107): 4.64e-42: 142: 40.39		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Hs
		531975 PDIA4_HUMAN (3-115): 1.12e-20: 93.7: 18.33		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Hs
		1067829 PDIA6_HUMAN (5-158): 2.41e-30: 119: 15.63		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		1067749 PDIA6_HUMAN (5-158): 2.41e-30: 119: 15.63		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		671821 PDIA3_HUMAN (5-116): 2.37e-22: 98.3: 15.25		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Hs
		423237 PDIA1_HUMAN (5-105): 1.71e-20: 92.9: 17.76		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27