HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1573 Hs			1 671
+	Hs
		203192 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28
+	Rn
		192744 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SRBS2_RAT (56-671): 3.74e-63: 229: 27.36
+	Hs
		203250 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53
+	Hs
		203262 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		PACN2_HUMAN (433-671): 4.38e-18: 89.7: 15.98
+	Hs
		203228 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02
+	Hs
		203241 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86
+	Hs
		203230 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH319_HUMAN (39-671): 7.07e-13: 73.9: 10.88
+	Hs
		166049 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02
+	Hs
		166056 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN2_HUMAN (116-671): 3.14e-15: 82: 10.46
+	Hs
		166055 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86
+	Hs
		166060 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		CD2AP_HUMAN (614-671): 8.75e-11: 67.2: 27.12
+	Dm
		112574 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		M9ND00_DROME (44-544): 9.5e-32: 134: 15.98
+	Ce
		104677 SYNJ_CAEEL (5-1160): 0: 938: 39.64		SRBS1_CAEEL (182-671): 5.35e-11: 68.2: 11.88
+	Hs
		298971 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28
+	Mm
		1208606 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		PLCG2_MOUSE (475-671): 1.83e-16: 85.8: 13.07
+	Mm
		1246940 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		SH3K1_MOUSE (614-671): 2.08e-13: 75.5: 25.86
+	Mm
		1141165 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		GRB2_MOUSE (615-669): 2.48e-14: 74.6: 28.57
+	Hs
		1271562 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86
+	Hs
		1271571 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		CD2AP_HUMAN (614-671): 8.75e-11: 67.2: 27.12
+	Hs
		968139 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94