HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16137687
Identification Methods	peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0012506 - vesicle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1573 Hs			1 377
+	Hs
		203192 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		203230 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84
+	Hs
		203228 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		203218 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Rn
		192744 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SRBS2_RAT (3-162): 4.86e-25: 109: 28.05
+	Hs
		203241 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		166030 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		166032 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		166024 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		166049 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		166042 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		166056 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05
+	Hs
		166055 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Ce
		105280 SYNJ_CAEEL (5-1160): 0: 938: 39.64		Q95PW9_CAEEL (1-376): 2.62e-70: 227: 38.69
+	Dm
		993185 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		GRAP_DROME (1-61): 1.53e-17: 82.3: 31.15
+	Dm
		112574 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		M9ND00_DROME (1-66): 4.46e-15: 78.8: 26.47
+	Mm
		643112 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Mm
		403460 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		SRC_MOUSE (5-114): 1.55e-15: 79.7: 22.32
+	Mm
		1141165 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03
+	Hs
		433436 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27