HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048488 - synaptic vesicle endocytosis GO:0098793 - presynapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1573 Hs			1 937
+	Hs
		203223 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		203194 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Rn
		1144064 SYNJ1_RAT (1-1573): 0: 1317: 88.27		Q66HM2_RAT (11-932): 0: 590: 16.38
+	Sc
		730448 INP53_YEAST (33-1087): 0: 827: 26.72		AP1B1_YEAST (12-697): 3.62e-180: 540: 35.84
+	Hs
		925855 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		968133 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		863347 SAC1_HUMAN (12-521): 1.37e-172: 532: 27.07		COPB_HUMAN (8-927): 0: 561: 12.47
+	Hs
		321531 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302140 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		212621 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57