HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35914814, 18539136
Identification Methods	two hybrid, affinity chromatography technology, two hybrid fragment pooling approach, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1573 Hs			1 1721
+	Hs
		166049 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		166056 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		203230 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH319_HUMAN (1079-1218): 3.12e-09: 63.9: 28.57
+	Hs
		203208 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Rn
		1126747 SYNJ1_RAT (1-1573): 0: 1317: 88.27		Q5JC29_RAT (529-841): 5.46e-10: 66.6: 12.00
+	Ce
		105276 SYNJ_CAEEL (5-1160): 0: 938: 39.64		O76572_CAEEL (1089-1615): 1.97e-73: 261: 18.15
+	Ce
		105278 SYNJ_CAEEL (5-1160): 0: 938: 39.64		VAV_CAEEL (1160-1566): 7.98e-66: 245: 16.74
+	Hs
		166030 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Dm
		112574 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		M9ND00_DROME (713-1252): 3.91e-15: 83.6: 12.73
+	Ce
		105281 SYNJ_CAEEL (5-1160): 0: 938: 39.64		Q9U2T9_CAEEL (708-1241): 6.47e-10: 66.6: 11.25
+	Hs
		506634 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		BCR_HUMAN (732-1682): 1.5e-71: 266: 12.45
+	Hs
		557759 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75