HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	9341169, 29054882, 11292345
Identification Methods	pull down, affinity chromatography technology, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016191 - synaptic vesicle uncoating GO:0048471 - perinuclear region of cytoplasm GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1573 Hs			1 352
+	Hs
		203248 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Rn
		192354 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G2_RAT (1-352): 2.12e-95: 289: 98.58
+	Mm
		88459 D3Z656_MOUSE (1-1573): 0: 1312: 88.66		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Mm
		88460 D3Z656_MOUSE (1-1573): 0: 1312: 88.66		SH3G3_MOUSE (1-351): 3.62e-90: 276: 64.67
+	Rn
		192356 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G3_RAT (1-352): 2.37e-87: 268: 65.06
+	Rn
		193638 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G1_RAT (1-352): 4.69e-84: 261: 69.57
+	Hs
		203218 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		203192 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92
+	Hs
		203230 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Rn
		192744 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SRBS2_RAT (295-352): 1.15e-10: 65.1: 34.72
+	Dm
		1137151 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		SH3G3_DROME (1-352): 1.11e-74: 236: 47.97
+	Hs
		166042 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Ce
		70018 SYNJ_CAEEL (5-1160): 0: 938: 39.64		SH3GH_CAEEL (1-350): 5e-70: 225: 43.19
+	Dm
		993185 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		GRAP_DROME (274-344): 7.28e-20: 88.3: 38.03
+	Dm
		112574 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		M9ND00_DROME (293-346): 3.57e-12: 69.5: 29.63
+	Mm
		1141165 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Mm
		1246940 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00
+	Hs
		924742 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		924485 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		298971 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92