HitPredict

Interactor 1: SUV91 (O43463)
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Gene: SUV39H1

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	36089195, 16858404, 33691908, 35907431, 16449642, 16409643, 11242053
Identification Methods	proximity labelling technology, enzymatic study, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 136
+	Hs
		203664 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		203722 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		203706 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H37_HUMAN (1-136): 5.62e-59: 180: 97.06
+	Hs
		203711 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		935237 SUV92_HUMAN (2-411): 3.41e-148: 428: 57.45		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952627 SUV92_HUMAN (2-411): 3.41e-148: 428: 57.45		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Dm
		356073 SUV39_DROME (26-412): 1.78e-88: 282: 33.26		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Mm
		952777 EHMT2_MOUSE (81-408): 6.88e-84: 280: 31.58		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		935126 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086279 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952553 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174632 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		935251 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086320 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952633 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	At
		886462 SUVH4_ARATH (86-412): 6.4e-81: 262: 22.89		H33_ARATH (1-136): 7.67e-62: 187: 96.32
+	Hs
		935276 ASH1L_HUMAN (67-409): 1.04e-72: 249: 21.39		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952649 ASH1L_HUMAN (67-409): 1.04e-72: 249: 21.39		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		935204 SETD2_HUMAN (87-411): 1.48e-67: 234: 24.26		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		828381 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00