HitPredict

Interactor 1: SUV91 (O43463)
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Gene: SUV39H1

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	17172641, 36089195
Identification Methods	enzymatic study, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 136
+	Hs
		203659 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		203722 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		203706 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		203711 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		935237 SUV92_HUMAN (2-411): 3.41e-148: 428: 57.45		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952627 SUV92_HUMAN (2-411): 3.41e-148: 428: 57.45		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Dm
		356073 SUV39_DROME (26-412): 1.78e-88: 282: 33.26		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Mm
		952777 EHMT2_MOUSE (81-408): 6.88e-84: 280: 31.58		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		935126 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952553 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086279 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1174632 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		935251 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952633 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086320 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	At
		886462 SUVH4_ARATH (86-412): 6.4e-81: 262: 22.89		H33_ARATH (1-136): 3.83e-60: 183: 95.59
+	Hs
		935276 ASH1L_HUMAN (67-409): 1.04e-72: 249: 21.39		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952649 ASH1L_HUMAN (67-409): 1.04e-72: 249: 21.39		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		828381 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		935204 SETD2_HUMAN (87-411): 1.48e-67: 234: 24.26		H31_HUMAN (1-136): 3.08e-60: 183: 96.32