HitPredict

Interactor 1: SUV91 (O43463)
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Gene: SUV39H1

Interactor 2: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	23455924
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding and 1 others more... GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 447
+	Hs
		203652 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		NR1H2_HUMAN (12-447): 3.47e-127: 377: 61.96
+	Hs
		203613 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		203691 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		Q15156_HUMAN (96-447): 1.84e-112: 350: 33.33
+	Hs
		203617 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		RARA_HUMAN (15-447): 1.17e-111: 338: 29.00
+	Hs
		203618 SUV91_HUMAN (1-412): 2.55e-163: 467: 100.00		THA_HUMAN (95-410): 1.92e-49: 177: 34.05
+	Hs
		370223 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		370465 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Mm
		1142741 EHMT2_MOUSE (81-408): 6.88e-84: 280: 31.58		ERR2_MOUSE (9-446): 1.81e-113: 342: 23.41
+	Hs
		782635 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		HNF4A_HUMAN (74-443): 1.56e-112: 340: 26.08
+	Hs
		782659 EHMT1_HUMAN (112-408): 1.23e-80: 271: 32.13		HNF4A_HUMAN (74-443): 1.56e-112: 340: 26.08
+	Mm
		1125427 EHMT1_MOUSE (75-408): 5.46e-78: 264: 31.29		ERR2_MOUSE (9-446): 1.81e-113: 342: 23.41
+	Hs
		1269380 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		370370 SETD2_HUMAN (87-411): 1.48e-67: 234: 24.26		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		370224 NSD1_HUMAN (123-411): 2.72e-65: 228: 24.14		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Mm
		93590 SETD2_MOUSE (87-411): 1.2e-66: 232: 23.67		ERR2_MOUSE (9-446): 1.81e-113: 342: 23.41
+	Hs
		488013 NSD1_HUMAN (123-411): 2.72e-65: 228: 24.14		RARA_HUMAN (15-447): 1.17e-111: 338: 29.00
+	Hs
		509984 SETD2_HUMAN (87-411): 1.48e-67: 234: 24.26		VDR_HUMAN (95-446): 9.2e-109: 329: 32.21
+	Hs
		1269543 SETD2_HUMAN (87-411): 1.48e-67: 234: 24.26		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		490071 NSD1_HUMAN (123-411): 2.72e-65: 228: 24.14		NR2F6_HUMAN (59-443): 3.86e-101: 309: 25.32
+	Hs
		975467 EHMT2_HUMAN (81-408): 1.21e-82: 276: 31.58		PPARD_HUMAN (95-443): 7.31e-38: 144: 29.95