Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 28642151, 15201285, 17266347
Identification Methods pull down, enzymatic study, unspecified method, molecular sieving
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PDZ_6~PDZ_6, PDZ_6~Trypsin_2, Trypsin_2~Trypsin_2
Common GO terms GO:0000785 - chromatin
GO:0004252 - serine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space
and 43 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 458
Hs

1 458
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ss
+ At
+ Ec
+ Ec
+ Ec
+ Hs
+ Sp
+ At
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024