Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2
Interactor 2: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.56 | 0.60 | 0.584 |
The method score is based on:
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043065 - positive regulation of apoptotic process GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0071300 - cellular response to retinoic acid |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
