HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	0.60	0.767

Property	Details
Experiments	24698088, 29631059, 11604410, 36243803, 15300255, 15781261, 11801603, 11803371, 11602612, 11583623, 12865429, 31617661, 15201285, 11606597, 17906618, 15200957, 12835328, 17311912, 28642151, 31470122
Identification Methods	pull down, affinity chromatography technology, unspecified method, proximity labelling technology, far western blotting, fluorescence polarization spectroscopy, anti tag coimmunoprecipitation, protease assay, coimmunoprecipitation, surface plasmon resonance and 1 others more... anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, biochemical, protein cleavage, cleavage reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0051402 - neuron apoptotic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 497
+	Mm
		1141992 HTRA2_MOUSE (1-458): 0: 549: 84.93		XIAP_MOUSE (1-497): 0: 544: 88.73
+	Hs
		949083 HTRA3_HUMAN (28-456): 3.06e-163: 469: 42.86		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		957747 HTRA1_HUMAN (26-455): 3.16e-146: 427: 41.05		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		949005 HTRA4_HUMAN (28-455): 1.19e-125: 375: 38.67		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Mm
		1143669 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC2_MOUSE (3-497): 5.52e-75: 249: 24.28
+	Hs
		203928 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Mm
		140034 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC3_MOUSE (150-342): 6.21e-40: 154: 27.16
+	Hs
		203927 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Mm
		57638 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC7_MOUSE (43-242): 2.28e-32: 126: 25.50
+	Hs
		204017 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83
+	Hs
		204028 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC8_HUMAN (160-264): 3.74e-31: 122: 30.48
+	Hs
		204062 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC6_HUMAN (258-442): 3.1e-26: 115: 18.78
+	Hs
		204007 HTRA2_HUMAN (1-458): 0: 528: 100.00		MYLIP_HUMAN (430-496): 3.78e-23: 103: 35.82
+	Dm
		1097138 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP2_DROME (14-98): 7.09e-22: 100: 34.12
+	Dm
		1097061 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP1_DROME (243-424): 7.45e-17: 84.6: 20.21