HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	12865429, 30948266, 11583623, 11606597
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 604
+	Mm
		140034 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC3_MOUSE (3-604): 0: 662: 73.92
+	Hs
		203928 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Mm
		1143669 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC2_MOUSE (3-604): 0: 619: 70.20
+	Mm
		1141992 HTRA2_MOUSE (1-458): 0: 549: 84.93		XIAP_MOUSE (147-604): 9.05e-80: 262: 24.00
+	Hs
		203914 HTRA2_HUMAN (1-458): 0: 528: 100.00		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		949083 HTRA3_HUMAN (28-456): 3.06e-163: 469: 42.86		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		957747 HTRA1_HUMAN (26-455): 3.16e-146: 427: 41.05		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		204062 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC6_HUMAN (7-136): 3.42e-35: 144: 20.29
+	Hs
		204017 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC7_HUMAN (13-165): 1.87e-34: 134: 21.80
+	Mm
		57638 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC7_MOUSE (340-604): 1.93e-27: 113: 23.62
+	Hs
		949005 HTRA4_HUMAN (28-455): 1.19e-125: 375: 38.67		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		204028 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC8_HUMAN (166-287): 8.71e-28: 113: 30.83
+	Hs
		204007 HTRA2_HUMAN (1-458): 0: 528: 100.00		MYLIP_HUMAN (479-603): 3.16e-23: 104: 25.60
+	Dm
		1097138 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP2_DROME (9-100): 4.66e-25: 110: 31.52
+	Dm
		1097061 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP1_DROME (20-173): 1.43e-24: 108: 24.36