HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: MK14 (Q16539)
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
Gene: MAPK14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	10644717, 17906618
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 360
+	Hs
		203895 HTRA2_HUMAN (1-458): 0: 528: 100.00		MK12_HUMAN (1-351): 1.68e-146: 420: 62.99
+	Hs
		203943 HTRA2_HUMAN (1-458): 0: 528: 100.00		MK11_HUMAN (1-348): 2.11e-145: 417: 75.58
+	Hs
		173800 HTRA2_HUMAN (1-458): 0: 528: 100.00		MK13_HUMAN (4-360): 1.04e-142: 410: 59.78
+	Hs
		203877 HTRA2_HUMAN (1-458): 0: 528: 100.00		MK03_HUMAN (11-354): 1.1e-141: 408: 47.86
+	Hs
		647542 HTRA4_HUMAN (28-455): 1.19e-125: 375: 38.67		MK03_HUMAN (11-354): 1.1e-141: 408: 47.86