HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: MUL1 (Q969V5)
Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)
Gene: MUL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	24709290
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0016020 - membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 352
+	Mm
		1143669 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC2_MOUSE (63-352): 2.45e-66: 221: 14.13
+	Mm
		140034 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC3_MOUSE (48-352): 1.78e-60: 205: 12.87
+	Hs
		203927 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC3_HUMAN (36-352): 1.47e-66: 222: 15.25
+	Mm
		1141992 HTRA2_MOUSE (1-458): 0: 549: 84.93		XIAP_MOUSE (63-352): 3.13e-59: 200: 13.18
+	Hs
		203928 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC2_HUMAN (63-352): 1.03e-62: 212: 13.06
+	Hs
		203914 HTRA2_HUMAN (1-458): 0: 528: 100.00		XIAP_HUMAN (63-352): 5.05e-61: 205: 12.84
+	Hs
		204028 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC8_HUMAN (65-352): 1.11e-58: 191: 11.91
+	Hs
		949083 HTRA3_HUMAN (28-456): 3.06e-163: 469: 42.86		XIAP_HUMAN (63-352): 5.05e-61: 205: 12.84
+	Mm
		57638 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC7_MOUSE (260-352): 4.3e-19: 88: 26.88
+	Hs
		957747 HTRA1_HUMAN (26-455): 3.16e-146: 427: 41.05		XIAP_HUMAN (63-352): 5.05e-61: 205: 12.84
+	Hs
		204017 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC7_HUMAN (15-192): 1.38e-18: 86.6: 10.75
+	Hs
		204007 HTRA2_HUMAN (1-458): 0: 528: 100.00		MYLIP_HUMAN (301-350): 2.89e-10: 63.3: 32.00
+	Hs
		949005 HTRA4_HUMAN (28-455): 1.19e-125: 375: 38.67		XIAP_HUMAN (63-352): 5.05e-61: 205: 12.84
+	Dm
		1097138 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP2_DROME (63-352): 2.19e-65: 216: 14.79
+	Dm
		1097061 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP1_DROME (270-352): 3.95e-19: 89.9: 26.51