HitPredict

Interactor 1: WIPF1 (O43516)
WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)
Gene: WIPF1

Interactor 2: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.717

Property	Details
Experiments	26186194, 28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Hs			1 380
+	Hs
		209187 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00
+	Hs
		206680 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		166030 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		557823 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		206699 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31
+	Hs
		166056 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31
+	Hs
		206676 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		206677 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		HCK_HUMAN (2-145): 5.1e-23: 102: 24.83
+	Hs
		166032 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		P85A_HUMAN (166-379): 4.05e-24: 106: 16.36
+	Hs
		655502 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		P85A_HUMAN (166-379): 4.05e-24: 106: 16.36
+	Hs
		166024 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		412404 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		442894 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		HCK_HUMAN (2-145): 5.1e-23: 102: 24.83
+	Hs
		166049 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23
+	Hs
		206685 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		206693 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35
+	Hs
		166042 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		924943 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		166055 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35
+	Hs
		523197 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55