HitPredict

Interactor 1: WIPF1 (O43516)
WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)
Gene: WIPF1

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	26496610, 33961781, 9694849, 10878810, 12620186
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Hs			1 377
+	Hs
		166030 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		557823 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		206669 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		209187 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		789012 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		TEC_HUMAN (27-377): 4.7e-38: 146: 17.63
+	Hs
		206676 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		166032 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		206677 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		655502 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		166024 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		412404 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		442894 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		206685 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		166049 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		166042 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		523197 ASAP1_HUMAN (12-437): 1.91e-27: 118: 19.59		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		206699 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05
+	Hs
		166056 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05
+	Hs
		206693 WIPF1_HUMAN (1-503): 1.19e-30: 126: 100.00		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		166055 SYNJ2_HUMAN (11-462): 6.97e-28: 120: 15.62		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76