HitPredict

Interactor 1: B2L11 (O43521)
Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
Gene: BCL2L11

Interactor 2: B2LA1 (Q16548)
Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS)
Gene: BCL2A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.888

The method score is based on:

Property Details
Experiments 16697956, 32296183, 9731710, unassigned1304
Identification Methods unspecified method, two hybrid, validated two hybrid, fluorescence polarization spectroscopy, two hybrid array, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Bcl-2~Bclx_interact
Common GO terms GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043065 - positive regulation of apoptotic process
GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 198
Hs

1 175
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024