HitPredict

Interactor 1: FOXO3 (O43524)
Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
Gene: FOXO3

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.651

The method score is based on:

Property Details
Experiments 21775285, 21621563, 10102273
Identification Methods enzymatic study, affinity technology, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006417 - regulation of translation
and 5 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 673
Hs

1 480
+ Rn
+ Mm
+ Hs
+ Hs
+ Dm
+ Dm
+ Ce
+ Ce
+ Hs
+ Sp
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024