HitPredict

Interactor 1: FOXO3 (O43524)
Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
Gene: FOXO3

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	20562859, 33961781, 35271311, 36931259, 24255178, 19940129, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 673 Hs			1 246
+	Hs
		206820 FOXO3_HUMAN (1-673): 3.29e-111: 351: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		206822 FOXO3_HUMAN (1-673): 3.29e-111: 351: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		206799 FOXO3_HUMAN (1-673): 3.29e-111: 351: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		206819 FOXO3_HUMAN (1-673): 3.29e-111: 351: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		206829 FOXO3_HUMAN (1-673): 3.29e-111: 351: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		206808 FOXO3_HUMAN (1-673): 3.29e-111: 351: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		909490 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683300 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		926976 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		46293 A0A1X9RU27_HUMAN (7-673): 2.83e-60: 213: 33.93		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		646840 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		46292 A0A1X9RU27_HUMAN (7-673): 2.83e-60: 213: 33.93		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		683265 FOXK1_HUMAN (25-558): 9.97e-43: 166: 15.37		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		904497 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		981960 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		46294 A0A1X9RU27_HUMAN (7-673): 2.83e-60: 213: 33.93		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		646796 FOXK1_HUMAN (25-558): 9.97e-43: 166: 15.37		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		46295 A0A1X9RU27_HUMAN (7-673): 2.83e-60: 213: 33.93		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		683999 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		904442 FOXK1_HUMAN (25-558): 9.97e-43: 166: 15.37		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40