HitPredict

Interactor 1: FOXO3 (O43524)
Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
Gene: FOXO3

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	26280018, 20562859, 35271311, 36931259, 17979178
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 255
+	Hs
		909490 FOXO1_HUMAN (11-673): 5.28e-65: 228: 39.44		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909439 FOXK1_HUMAN (25-558): 9.97e-43: 166: 15.37		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909442 FOXO4_HUMAN (90-643): 9.6e-38: 149: 33.57		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Dm
		955013 FOXO_DROME (98-480): 1.85e-40: 158: 32.83		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Sc
		664890 FKH2_YEAST (50-615): 1.11e-40: 161: 13.83		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72
+	Hs
		909499 FOXC1_HUMAN (161-239): 2.36e-10: 65.5: 43.21		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00