HitPredict

Interactor 1: FOXO3 (O43524)
Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
Gene: FOXO3

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.704

The method score is based on:

Property Details
Experiments 15126506, 20733005, 14976264, 21713995
Identification Methods affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation, deacetylase assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001542 - ovulation from ovarian follicle
GO:0005634 - nucleus
and 7 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 673
Hs

1 747
+ Hs
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+ Mm
+ Hs
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+ Ce
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+ Sc
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+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024