HitPredict

Interactor 1: SMAD6 (O43541)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
Gene: SMAD6

Interactor 2: ACV1B (P36896)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: ACVR1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20663871
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0046872 - metal ion binding GO:0070411 - I-SMAD binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 496 Hs			1 505
+	Mm
		192362 SMAD6_MOUSE (1-496): 0: 694: 92.17		BMR1A_MOUSE (19-505): 2.62e-144: 426: 49.49
+	Mm
		192363 SMAD6_MOUSE (1-496): 0: 694: 92.17		BMR1B_MOUSE (19-505): 1.13e-143: 423: 50.20
+	Hs
		206939 SMAD6_HUMAN (1-496): 0: 674: 100.00		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Mm
		192364 SMAD6_MOUSE (1-496): 0: 694: 92.17		ACVR1_MOUSE (12-502): 1.51e-135: 403: 48.20
+	Hs
		122278 SMAD6_HUMAN (1-496): 0: 674: 100.00		BMR1B_HUMAN (19-505): 8.25e-143: 421: 49.80
+	Hs
		206941 SMAD6_HUMAN (1-496): 0: 674: 100.00		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		206953 SMAD6_HUMAN (1-496): 0: 674: 100.00		ACVR1_HUMAN (12-502): 2.83e-137: 407: 48.20
+	Hs
		206958 SMAD6_HUMAN (1-496): 0: 674: 100.00		AVR2B_HUMAN (51-502): 1.1e-107: 331: 30.87
+	Mm
		192359 SMAD6_MOUSE (1-496): 0: 694: 92.17		BMPR2_MOUSE (1-497): 3.7e-93: 306: 28.11
+	Hs
		206959 SMAD6_HUMAN (1-496): 0: 674: 100.00		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		738442 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		ACV1B_HUMAN (1-505): 2.52e-154: 451: 100.00
+	Hs
		738454 SMAD2_HUMAN (169-495): 3.35e-141: 415: 26.59		ACV1B_HUMAN (1-505): 2.52e-154: 451: 100.00
+	Hs
		738353 SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Hs
		738526 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		738548 SMAD2_HUMAN (169-495): 3.35e-141: 415: 26.59		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		981121 SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01		ACVR1_HUMAN (12-502): 2.83e-137: 407: 48.20
+	Hs
		981137 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		ACVR1_HUMAN (12-502): 2.83e-137: 407: 48.20
+	Hs
		739529 SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01		ACVL1_HUMAN (13-502): 5.72e-134: 398: 46.96
+	Dm
		785472 MAD_DROME (169-495): 4.33e-150: 437: 28.35		Q95SI0_DROME (18-500): 5.67e-126: 378: 43.68
+	Hs
		739949 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		TGFR2_HUMAN (69-499): 4.18e-121: 368: 31.05