HitPredict

Interactor 1: SMAD6 (O43541)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
Gene: SMAD6

Interactor 2: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	9436979, 20663871
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0031625 - ubiquitin protein ligase binding GO:0046872 - metal ion binding GO:0070411 - I-SMAD binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 496 Hs			1 503
+	Mm
		192363 SMAD6_MOUSE (1-496): 0: 694: 92.17		BMR1B_MOUSE (22-503): 1.21e-135: 403: 51.74
+	Mm
		192362 SMAD6_MOUSE (1-496): 0: 694: 92.17		BMR1A_MOUSE (21-503): 3.3e-134: 400: 51.32
+	Mm
		192364 SMAD6_MOUSE (1-496): 0: 694: 92.17		ACVR1_MOUSE (10-500): 6.1e-134: 398: 48.50
+	Hs
		206953 SMAD6_HUMAN (1-496): 0: 674: 100.00		ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30
+	Hs
		122278 SMAD6_HUMAN (1-496): 0: 674: 100.00		BMR1B_HUMAN (22-503): 1.21e-134: 400: 51.53
+	Hs
		206939 SMAD6_HUMAN (1-496): 0: 674: 100.00		BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92
+	Hs
		206940 SMAD6_HUMAN (1-496): 0: 674: 100.00		ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78
+	Hs
		206958 SMAD6_HUMAN (1-496): 0: 674: 100.00		AVR2B_HUMAN (53-498): 2.08e-105: 325: 30.50
+	Mm
		192359 SMAD6_MOUSE (1-496): 0: 694: 92.17		BMPR2_MOUSE (48-495): 8.86e-92: 303: 29.00
+	Hs
		206959 SMAD6_HUMAN (1-496): 0: 674: 100.00		BMPR2_HUMAN (48-495): 1.21e-92: 305: 29.21
+	Hs
		738526 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00
+	Hs
		738548 SMAD2_HUMAN (169-495): 3.35e-141: 415: 26.59		TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00
+	Hs
		981121 SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01		ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30
+	Hs
		981137 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30
+	Hs
		738353 SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01		BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92
+	Hs
		738442 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78
+	Hs
		738454 SMAD2_HUMAN (169-495): 3.35e-141: 415: 26.59		ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78
+	Hs
		739529 SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01		ACVL1_HUMAN (6-498): 2.71e-130: 389: 47.21
+	Dm
		785472 MAD_DROME (169-495): 4.33e-150: 437: 28.35		Q95SI0_DROME (31-497): 6.57e-122: 368: 45.13
+	Hs
		739949 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94