HitPredict

Interactor 1: SMAD6 (O43541)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
Gene: SMAD6

Interactor 2: ACVR1 (Q04771)
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 20663871, 23455153
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003183 - mitral valve morphogenesis
GO:0007179 - transforming growth factor beta receptor signaling pathway
GO:0030509 - BMP signaling pathway
GO:0032926 - negative regulation of activin receptor signaling pathway
GO:0046872 - metal ion binding
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 496
Hs

1 509
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+ Mm
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+ Dm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024