HitPredict

Interactor 1: SMAD6 (O43541)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
Gene: SMAD6

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15359284, 15221015, 24850914
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 496 Hs			1 922
+	Hs
		206970 SMAD6_HUMAN (1-496): 0: 674: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125023 SMAD6_HUMAN (1-496): 0: 674: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		206971 SMAD6_HUMAN (1-496): 0: 674: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		206944 SMAD6_HUMAN (1-496): 0: 674: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		1305881 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		950278 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		950248 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Dm
		785516 MAD_DROME (169-495): 4.33e-150: 437: 28.35		SUDX_DROME (14-922): 0: 832: 52.00
+	Hs
		125369 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		950249 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808087 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808240 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		206977 SMAD6_HUMAN (1-496): 0: 674: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		206976 SMAD6_HUMAN (1-496): 0: 674: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Mm
		192368 SMAD6_MOUSE (1-496): 0: 694: 92.17		SMUF1_MOUSE (276-436): 5.09e-16: 84.9: 21.14
+	Hs
		1305888 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1305886 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Dm
		785477 MAD_DROME (169-495): 4.33e-150: 437: 28.35		SMUF1_DROME (16-538): 1.82e-25: 115: 13.02
+	Hs
		950287 SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		1305892 SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11