HitPredict

Interactor 1: XRCC3 (O43542)
DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)
Gene: XRCC3

Interactor 2: BRCA2 (P51587)
Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)
Gene: BRCA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	26496610, 20450923, 18212739, 16621732, 24141787
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BRCA2~Rad51
Common GO terms	GO:0000722 - telomere maintenance via recombination GO:0000724 - double-strand break repair via homologous recombination GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 3418
+	Hs
		847792 RAD51_HUMAN (3-342): 6.58e-110: 325: 22.58		BRCA2_HUMAN (1-3418): 0: 5420: 100.00
+	Hs
		847801 DMC1_HUMAN (3-342): 1.41e-99: 299: 21.41		BRCA2_HUMAN (1-3418): 0: 5420: 100.00
+	Hs
		206272 RA51C_HUMAN (2-345): 8.58e-88: 270: 24.04		BRCA2_HUMAN (1-3418): 0: 5420: 100.00
+	Cl
		1228470 RAD51_CANLF (3-342): 4.57e-109: 323: 22.58		Q8MKI9_CANLF (1-3416): 0: 5073: 69.08
+	Mm
		957078 RAD51_MOUSE (3-342): 7.1e-110: 325: 22.58		BRCA2_MOUSE (1-3370): 0: 4745: 57.32
+	Mm
		193398 RA51B_MOUSE (2-337): 9.45e-85: 261: 25.64		BRCA2_MOUSE (1-3370): 0: 4745: 57.32
+	At
		955961 RAD51_ARATH (2-342): 1.69e-103: 309: 24.85		BRC2A_ARATH (2519-3107): 0: 731: 28.52
+	At
		955960 RAD51_ARATH (2-342): 1.69e-103: 309: 24.85		BRC2B_ARATH (2519-3107): 0: 730: 28.86
+	At
		1105526 DMC1_ARATH (2-342): 1.28e-97: 294: 22.52		BRC2A_ARATH (2519-3107): 0: 731: 28.52
+	At
		1105525 DMC1_ARATH (2-342): 1.28e-97: 294: 22.52		BRC2B_ARATH (2519-3107): 0: 730: 28.86