HitPredict

Interactor 1: TNF14 (O43557)
Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
Gene: TNFSF14

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	12571250
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006915 - apoptotic process GO:0043027 - cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 240 Hs			1 618
+	Hs
		352608 TNFA_HUMAN (22-240): 8.18e-70: 215: 24.11		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		669885 CD40L_HUMAN (31-240): 5.75e-49: 163: 23.72		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		352415 TNFB_HUMAN (75-240): 7.3e-43: 145: 25.86		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		352607 TNFA_HUMAN (22-240): 8.18e-70: 215: 24.11		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		669884 CD40L_HUMAN (31-240): 5.75e-49: 163: 23.72		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		352678 TNFA_HUMAN (22-240): 8.18e-70: 215: 24.11		MIB2_HUMAN (558-617): 3.21e-10: 65.3: 36.67