Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT

Interactor 2: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.651

The method score is based on:

Property Details
Experiments 11368773, 12186560, 23514740
Identification Methods enzymatic study, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001772 - immunological synapse
GO:0002250 - adaptive immune response
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0006955 - immune response
and 4 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 262
Hs

1 619
+ Hs
+ Hs
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+ Mm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024