HitPredict

Interactor 1: XPOT (O43592)
Exportin-T (Exportin(tRNA)) (tRNA exportin)
Gene: XPOT

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	24797263, 35384245, 23956138, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 962 Hs			1 1210
+	Hs
		162322 XPO1_HUMAN (1-961): 1.34e-151: 477: 14.33		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338800 TNPO1_HUMAN (10-919): 7.97e-129: 413: 12.88		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		155507 TNPO2_HUMAN (10-919): 8.28e-122: 394: 12.34		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		162768 XPO1_HUMAN (1-961): 1.34e-151: 477: 14.33		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		297142 IPO13_HUMAN (2-961): 2.27e-110: 365: 12.77		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339200 TNPO3_HUMAN (1-961): 1.17e-109: 362: 13.31		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339000 XPO5_HUMAN (1-879): 3.25e-103: 350: 13.26		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		162330 XPO1_HUMAN (1-961): 1.34e-151: 477: 14.33		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		338865 XPO6_HUMAN (13-957): 5.43e-85: 298: 11.17		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383912 TNPO1_HUMAN (10-919): 7.97e-129: 413: 12.88		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		162344 XPO1_HUMAN (1-961): 1.34e-151: 477: 14.33		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		435716 TNPO1_HUMAN (10-919): 7.97e-129: 413: 12.88		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		435766 XPO5_HUMAN (1-879): 3.25e-103: 350: 13.26		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47