HitPredict

Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2

Interactor 2: AAKB2 (O43741)
5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
Gene: PRKAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	25416956, 32296183, 24722188
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 315 Hs			1 272
+	Hs
		212452 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		AAKB2_HUMAN (1-272): 1.07e-131: 375: 100.00
+	Hs
		208311 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		AAKB2_HUMAN (1-272): 1.07e-131: 375: 100.00
+	Hs
		212451 SPRE1_HUMAN (142-277): 3.35e-39: 145: 25.18		AAKB2_HUMAN (1-272): 1.07e-131: 375: 100.00