HitPredict

Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2

Interactor 2: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 315 Hs			1 330
+	Hs
		275205 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00
+	Mm
		1208609 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		PLCG2_MOUSE (9-329): 3.85e-35: 137: 16.81
+	Hs
		1192446 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03
+	Hs
		208145 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		Q5JPT6_HUMAN (273-330): 1.35e-17: 85.7: 31.03
+	Hs
		208177 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03
+	Hs
		924668 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Hs
		208125 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Hs
		208142 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		ITSN1_HUMAN (86-329): 9.9e-12: 68: 12.99
+	Mm
		1246943 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		SH3K1_MOUSE (273-330): 1.5e-17: 85.3: 32.76
+	Hs
		208319 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08
+	Mm
		1141168 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89
+	Mm
		1351605 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		ITSN1_MOUSE (2-58): 1.83e-11: 67.2: 27.59
+	Hs
		208390 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03
+	Hs
		208348 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Hs
		924846 SPY4_HUMAN (4-305): 6.69e-92: 277: 40.78		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Mm
		1141172 SPY4_MOUSE (3-305): 1.03e-91: 276: 41.61		GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89
+	Mm
		1141169 SPY1_MOUSE (1-315): 8.67e-91: 274: 50.62		GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89
+	Hs
		208416 SPY3_HUMAN (39-305): 3.2e-89: 269: 44.89		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Mm
		1113312 SPRY3_MOUSE (39-313): 1.21e-88: 268: 43.86		GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89
+	Dm
		219699 SPY_DROME (152-294): 4.84e-48: 171: 45.03		GRAP_DROME (274-326): 4.18e-12: 66.5: 35.19