Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2
Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.767 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20622121, 11053437, 12234920, 16246327, 12593796, 12593795, 11983899, 20877636, 21596750, 17255109, 18273061, 17974561, 20124286, 20461437, 15962011, 12815057, 15004239, 16479008, 16893902 |
| Identification Methods | affinity chromatography technology, pull down, two hybrid, x-ray crystallography, fluorescent resonance energy transfer, coimmunoprecipitation, anti bait coimmunoprecipitation, isothermal titration calorimetry, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process GO:0045742 - positive regulation of epidermal growth factor receptor signaling pathway GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
