HitPredict

Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2

Interactor 2: Q5JPT6 (Q5JPT6)
GIG10 (Migration-inducing gene 18 protein) (cDNA, FLJ93821, Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1), mRNA)
Gene: Q5JPT6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.50	0.470

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 315 Hs			1 665
+	Hs
		1192446 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		208177 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Mm
		1246943 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		208390 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		924668 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208125 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		1141168 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		208142 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		275205 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		208081 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		208072 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		1351605 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Hs
		208348 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924846 SPY4_HUMAN (4-305): 6.69e-92: 277: 40.78		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		1141172 SPY4_MOUSE (3-305): 1.03e-91: 276: 41.61		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Mm
		1141169 SPY1_MOUSE (1-315): 8.67e-91: 274: 50.62		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		208416 SPY3_HUMAN (39-305): 3.2e-89: 269: 44.89		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		1113312 SPRY3_MOUSE (39-313): 1.21e-88: 268: 43.86		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91