HitPredict

Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	25416956, 32296183, 15962011
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 315 Hs			1 665
+	Hs
		1192446 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		208145 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		Q5JPT6_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Mm
		1246943 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		208390 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		924668 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208125 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		1141168 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		208142 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		275205 Q7Z783_HUMAN (1-312): 9.45e-138: 395: 98.72		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		208081 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		208072 SPY2_HUMAN (1-315): 1.24e-136: 391: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		1351605 SPY2_MOUSE (1-315): 1.04e-129: 373: 96.20		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Hs
		208348 SPY1_HUMAN (1-315): 1.06e-110: 325: 51.67		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924846 SPY4_HUMAN (4-305): 6.69e-92: 277: 40.78		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		1141172 SPY4_MOUSE (3-305): 1.03e-91: 276: 41.61		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Mm
		1141169 SPY1_MOUSE (1-315): 8.67e-91: 274: 50.62		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		208416 SPY3_HUMAN (39-305): 3.2e-89: 269: 44.89		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		1113312 SPRY3_MOUSE (39-313): 1.21e-88: 268: 43.86		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91