HitPredict

Interactor 1: SPY1 (O43609)
Protein sprouty homolog 1 (Spry-1)
Gene: SPRY1

Interactor 2: KR122 (P59991)
Keratin-associated protein 12-2 (High sulfur keratin-associated protein 12.2) (Keratin-associated protein 12.2)
Gene: KRTAP12-2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 319 Hs			1 146
+	Hs
		208398 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KRA93_HUMAN (5-140): 5.98e-27: 100: 25.95
+	Hs
		208342 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR103_HUMAN (1-145): 3.64e-26: 99.7: 30.97
+	Hs
		208346 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR109_HUMAN (5-130): 2.29e-20: 86.2: 29.37
+	Hs
		208396 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR412_HUMAN (6-141): 1.98e-20: 84.7: 25.63
+	Hs
		208383 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KRA13_HUMAN (4-145): 4.05e-19: 80.4: 22.60
+	Hs
		208343 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR105_HUMAN (3-119): 9.74e-18: 78.9: 25.68
+	Hs
		208347 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR10B_HUMAN (3-144): 4.4e-17: 77.4: 32.70
+	Hs
		208382 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR111_HUMAN (5-124): 4.24e-18: 77.4: 19.17
+	Hs
		208399 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KRA92_HUMAN (23-145): 2e-17: 76.2: 24.24
+	Hs
		208400 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KRA42_HUMAN (28-146): 7.21e-17: 73.5: 27.73
+	Hs
		208340 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR123_HUMAN (1-96): 3.44e-16: 70.8: 50.00
+	Hs
		208345 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR108_HUMAN (23-145): 8.65e-15: 70.8: 26.98
+	Hs
		208352 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KRA11_HUMAN (59-145): 5.86e-13: 64.3: 35.96
+	Hs
		208344 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR107_HUMAN (1-95): 3.28e-11: 61.6: 34.69
+	Hs
		208341 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		KR101_HUMAN (1-89): 5.61e-09: 54.6: 30.34
+	Hs
		208119 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		KR103_HUMAN (1-145): 3.64e-26: 99.7: 30.97
+	Hs
		208122 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		KR109_HUMAN (5-130): 2.29e-20: 86.2: 29.37
+	Hs
		208120 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		KR105_HUMAN (3-119): 9.74e-18: 78.9: 25.68
+	Hs
		208121 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		KR108_HUMAN (23-145): 8.65e-15: 70.8: 26.98
+	Hs
		208118 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		KR101_HUMAN (1-89): 5.61e-09: 54.6: 30.34