HitPredict

Interactor 1: SPY1 (O43609)
Protein sprouty homolog 1 (Spry-1)
Gene: SPRY1

Interactor 2: LCE1B (Q5T7P3)
Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A)
Gene: LCE1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.50	0.578

Property	Details
Experiments	25416956, 36949045
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 319 Hs			1 118
+	Hs
		208362 SPY1_HUMAN (1-319): 4.3e-127: 367: 100.00		LCE1C_HUMAN (1-118): 3.49e-50: 156: 96.61
+	Hs
		1134492 Q7Z783_HUMAN (1-313): 1.06e-108: 321: 52.32		LCE1C_HUMAN (1-118): 3.49e-50: 156: 96.61
+	Hs
		208148 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		LCE1C_HUMAN (1-118): 3.49e-50: 156: 96.61
+	Hs
		208151 SPY2_HUMAN (1-319): 1.92e-107: 317: 52.28		LCE1B_HUMAN (1-118): 4.85e-50: 156: 100.00
+	Hs
		1134491 SPRE2_HUMAN (18-286): 4.43e-81: 253: 21.63		LCE1C_HUMAN (1-118): 3.49e-50: 156: 96.61
+	Hs
		208424 SPY3_HUMAN (38-317): 1.7e-78: 242: 39.66		LCE1B_HUMAN (1-118): 4.85e-50: 156: 100.00