HitPredict

Interactor 1: OX1R (O43613)
Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R)
Gene: HCRTR1

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21378163
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 409
+	Hs
		208444 OX1R_HUMAN (1-425): 6.2e-99: 303: 100.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		428933 ADRB2_HUMAN (1-397): 1.79e-81: 258: 21.30		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663954 Q8VBU7_RAT (1-419): 4.27e-83: 262: 21.62		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		441648 ADRB1_HUMAN (4-395): 3.51e-74: 241: 22.14		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		656989 5HT2A_HUMAN (6-403): 2.55e-70: 231: 17.96		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		685822 OPRD_HUMAN (1-412): 6.64e-69: 224: 21.10		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		441649 ADRB1_HUMAN (4-395): 3.51e-74: 241: 22.14		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		781016 OPRD_HUMAN (1-412): 6.64e-69: 224: 21.10		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		663944 TRHR_RAT (59-375): 1.22e-30: 123: 28.84		ARRB1_RAT (1-399): 0: 654: 76.90