HitPredict

Interactor 1: OX1R (O43613)
Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R)
Gene: HCRTR1

Interactor 2: APJ (P35414)
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
Gene: APLNR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31668922
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~7tm_1
Common GO terms	GO:0004930 - G protein-coupled receptor activity GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 380
+	Hs
		723008 ADA1B_HUMAN (1-425): 6.63e-86: 273: 20.54		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		208443 OX1R_HUMAN (1-425): 6.2e-99: 303: 100.00		OPRK_HUMAN (5-342): 3.81e-67: 218: 25.29
+	Hs
		722931 ADA1A_HUMAN (25-386): 7.43e-78: 250: 20.05		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		686250 GASR_HUMAN (7-425): 1.17e-74: 241: 24.28		CCR4_HUMAN (7-329): 2.4e-81: 254: 29.45
+	Hs
		723007 ADA1B_HUMAN (1-425): 6.63e-86: 273: 20.54		ADA1B_HUMAN (3-378): 1.25e-66: 221: 16.43
+	Hs
		428881 ADRB2_HUMAN (1-397): 1.79e-81: 258: 21.30		ADRB2_HUMAN (1-349): 2e-70: 228: 20.47
+	Hs
		626678 ADA1B_HUMAN (1-425): 6.63e-86: 273: 20.54		ADA1D_HUMAN (31-376): 5.12e-63: 212: 18.30
+	Hs
		722929 ADA1B_HUMAN (1-425): 6.63e-86: 273: 20.54		ADA1A_HUMAN (9-377): 3.75e-63: 210: 18.54
+	Hs
		428883 ADRB1_HUMAN (4-395): 3.51e-74: 241: 22.14		ADRB2_HUMAN (1-349): 2e-70: 228: 20.47
+	Hs
		428934 GASR_HUMAN (7-425): 1.17e-74: 241: 24.28		ADRB2_HUMAN (1-349): 2e-70: 228: 20.47
+	Hs
		428952 ADRB2_HUMAN (1-397): 1.79e-81: 258: 21.30		OPRD_HUMAN (23-362): 1.55e-63: 209: 26.69
+	Hs
		626674 ADA1D_HUMAN (6-369): 2.15e-76: 249: 20.69		ADA1D_HUMAN (31-376): 5.12e-63: 212: 18.30
+	Hs
		1044519 5HT4R_HUMAN (43-425): 3.44e-75: 241: 23.26		5HT4R_HUMAN (25-378): 1.89e-67: 219: 20.27
+	Hs
		722928 ADA1A_HUMAN (25-386): 7.43e-78: 250: 20.05		ADA1A_HUMAN (9-377): 3.75e-63: 210: 18.54
+	Rn
		677499 SSR4_RAT (10-387): 6.38e-74: 238: 21.41		OPRD_RAT (3-362): 7.21e-63: 207: 25.21
+	Hs
		626812 ADA1B_HUMAN (1-425): 6.63e-86: 273: 20.54		ACKR3_HUMAN (34-317): 1.58e-36: 137: 29.27
+	Hs
		626811 ADA1A_HUMAN (25-386): 7.43e-78: 250: 20.05		ACKR3_HUMAN (34-317): 1.58e-36: 137: 29.27
+	Hs
		626675 ADA1D_HUMAN (6-369): 2.15e-76: 249: 20.69		ACKR3_HUMAN (34-317): 1.58e-36: 137: 29.27