HitPredict

Interactor 1: OX2R (O43614)
Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)
Gene: HCRTR2

Interactor 2: AT2B3 (Q16720)
Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)
Gene: ATP2B3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051480 - regulation of cytosolic calcium ion concentration
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 444 Hs			1 1220
+	Hs
		208453 OX2R_HUMAN (1-444): 2.57e-117: 352: 100.00		AT2B2_HUMAN (1-1220): 0: 1231: 81.07
+	Hs
		208448 OX2R_HUMAN (1-444): 2.57e-117: 352: 100.00		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		781059 OPRX_HUMAN (6-396): 9.21e-68: 222: 22.53		AT2B3_HUMAN (1-1220): 0: 1287: 100.00
+	Hs
		428921 ADRB2_HUMAN (50-443): 1.52e-81: 259: 22.42		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		666307 NK3R_HUMAN (4-417): 4.64e-69: 228: 22.41		AT2B2_HUMAN (1-1220): 0: 1231: 81.07
+	Hs
		781053 OPRX_HUMAN (6-396): 9.21e-68: 222: 22.53		AT2B2_HUMAN (1-1220): 0: 1231: 81.07
+	Hs
		619198 NK3R_HUMAN (4-417): 4.64e-69: 228: 22.41		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		619204 APJ_HUMAN (35-432): 2.77e-69: 226: 17.62		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		619206 OPRX_HUMAN (6-396): 9.21e-68: 222: 22.53		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		392982 ADRB2_HUMAN (50-443): 1.52e-81: 259: 22.42		AT1A1_HUMAN (13-1073): 0: 751: 21.63
+	Hs
		428908 ADRB2_HUMAN (50-443): 1.52e-81: 259: 22.42		AT2A2_HUMAN (50-1075): 0: 750: 24.20
+	Hs
		530839 NK3R_HUMAN (4-417): 4.64e-69: 228: 22.41		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		530964 NPFF1_HUMAN (11-442): 1.47e-68: 226: 24.71		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		530844 OPRX_HUMAN (6-396): 9.21e-68: 222: 22.53		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		561517 OPRD_HUMAN (6-409): 5.5e-69: 225: 19.70		AT2A2_HUMAN (50-1075): 0: 750: 24.20
+	Hs
		530834 NK1R_HUMAN (85-382): 1.73e-29: 120: 28.90		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		530938 PKR1_HUMAN (64-330): 1.44e-29: 120: 29.15		AT1A3_HUMAN (39-1073): 0: 756: 23.47