HitPredict

Interactor 1: SNAI2 (O43623)
Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
Gene: SNAI2

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	23011797, 23851495
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~zf-C2H2
Common GO terms	GO:0001837 - epithelial to mesenchymal transition GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 268 Hs			1 420
+	Hs
		326513 SNAI1_HUMAN (1-264): 8.56e-72: 222: 50.54		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		326683 SNAI1_HUMAN (1-264): 8.56e-72: 222: 50.54		Q6FI27_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Mm
		968964 SNAI1_MOUSE (1-264): 4.56e-72: 223: 50.74		GSK3B_MOUSE (1-408): 4.52e-162: 464: 99.02
+	Hs
		835598 ZN135_HUMAN (150-267): 5.05e-36: 137: 29.17		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00