HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 412
+	Hs
		235041 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00
+	Mm
		223005 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04
+	Mm
		250957 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04
+	Mm
		223011 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12
+	Hs
		209149 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53
+	Mm
		956524 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12
+	Hs
		557780 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53
+	Hs
		235051 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00
+	Hs
		208999 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		IRS1_HUMAN (1-339): 2.03e-69: 239: 15.90
+	Mm
		643076 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12
+	Hs
		209049 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		GAB1_HUMAN (2-157): 1.07e-15: 81.1: 17.28
+	Hs
		557681 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		GAB1_HUMAN (2-157): 1.07e-15: 81.1: 17.28
+	Hs
		209034 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		DYN1_HUMAN (5-351): 9.37e-09: 59.6: 12.85
+	Hs
		557834 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		GAB2_HUMAN (2-394): 4.27e-15: 79.2: 12.53
+	Mm
		643063 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		IRS1_MOUSE (1-339): 1.89e-73: 251: 16.36
+	Hs
		557664 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DYN1_HUMAN (5-351): 9.37e-09: 59.6: 12.85
+	Mm
		643075 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		IRS2_MOUSE (5-362): 1.3e-66: 231: 17.25
+	Mm
		69824 B1AT92_MOUSE (5-171): 1.06e-28: 112: 19.80		GAB2_MOUSE (2-143): 2.93e-15: 79.6: 18.67
+	Hs
		1040322 GRAP_HUMAN (5-169): 7.3e-28: 110: 15.74		GAB2_HUMAN (2-394): 4.27e-15: 79.2: 12.53
+	Mm
		643089 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		Q3ZB59_MOUSE (2-143): 3.23e-15: 79.6: 18.67