HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 802
+	Hs
		576988 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		PTPRA_HUMAN (1-802): 0: 1040: 100.00
+	Hs
		411997 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PTPRA_HUMAN (1-802): 0: 1040: 100.00
+	Rn
		1144045 FYN_RAT (7-137): 2.1e-23: 103: 20.30		Q66HJ7_RAT (1-802): 0: 1018: 94.16
+	Mm
		574000 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		PTPRA_MOUSE (1-802): 0: 1003: 90.69
+	Mm
		56907 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		PTPRF_MOUSE (4-799): 0: 905: 40.52
+	Hs
		412016 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PTPRD_HUMAN (38-799): 0: 897: 40.50
+	Hs
		411959 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PTPRF_HUMAN (4-799): 0: 894: 40.52
+	Hs
		617084 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRG_HUMAN (14-798): 0: 788: 29.12
+	Rn
		94284 FYN_RAT (7-137): 2.1e-23: 103: 20.30		F1LXJ9_RAT (48-795): 0: 784: 31.67
+	Hs
		782790 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRK_HUMAN (14-794): 0: 757: 32.41
+	Hs
		655375 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		PTPRK_HUMAN (14-794): 0: 757: 32.41
+	Hs
		557617 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80
+	Hs
		782783 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRJ_HUMAN (516-797): 1.76e-118: 390: 38.87
+	Hs
		616905 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRB_HUMAN (443-796): 5.85e-116: 389: 31.11
+	Hs
		782792 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRO_HUMAN (509-789): 1.49e-113: 375: 34.51
+	Hs
		655223 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47
+	Hs
		655218 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80
+	Hs
		441186 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRC_HUMAN (211-516): 1.3e-77: 275: 28.91
+	Hs
		411950 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PTPRC_HUMAN (211-516): 1.3e-77: 275: 28.91
+	Hs
		617158 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PTPRZ_HUMAN (240-516): 7.22e-53: 202: 28.13